AAV-DJ Virus-Like Particle

AAV virus-like particles (sometimes referred to as AAV empty capsids) are well-characterized AAV capsids devoid of any viral genomic material that are widely used as reference materials during the development of AAV-based gene therapies. AAV virus-like particles can not only be used for the calibration and optimization of various analytical assays including ELISA and HPLC, but they can be used for various other applications during the drug development process, including biodistribution assessment and evaluation of in vivo immune responses to specific serotypes of AAV capsid. Our ready-to-ship AAV virus-like particles are extensively characterized and therefore, serve as reliable standards for evaluating the quality of AAV virus-like particles generated in-house. Moreover, they can be used as negative controls in studies aiming to demonstrate that an observed effect is caused by the expression cassette harbored by an AAV vector rather than its capsid. AAV virus-like particles also serve as critical tools for studying various processes during the AAV life cycle including capsid assembly and post-translational modifications of capsid proteins. In addition to AAV virus-like particles, we also offer AAV packaging and GMP-grade AAV manufacturing.

Highlights
▪ Ready-to-ship in vivo grade AAV virus-like particles of serotypes 1, 2, 3, 5, 6, 8, 9, and 2-retro.
▪ Thorough characterization using various methods including SDS-PAGE, BCA, endotoxin testing, mycoplasma detection, and full/empty capsid ratio analysis

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