Name: A 484954
Price: 329.00 USD

- Overview
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    Background
    
    A 484954 is a selective inhibitor of eEF2K with IC50 value of 0.28 μM [1]. Eukaryotic elongation factor-2 kinase (eEF2K) is a calcium/calmodulin-dependent protein kinase and regulates protein synthesis. It phosphorylates eEF2 and inhibits the activity of eEF2 [1]. A 484954 is a selective eEF2K inhibitor. A 484954 inhibited eEF2K and the phosphorylation of eEF2. While, it didn’t inhibit cancer cell growth. In enzymatic assay, the IC50 value of A-484954 was increased in an ATP-dependent way but not affected by the concentrations of calmodulin. In H1299 cells, A 484954 inhibited the phosphorylation of eEF2 but didn’t affect the protein level of eEF2. In PC3 cells, A 484954 (10 μM) inhibited peEF2 by 50% and the inhibition reached the maximum level at 100 μM. While A 484954 didn’t inhibit cell proliferation. In PC3 cells, NH125 induced eEF2 phosphorylation, while A 484954 had little effect on peEF2 induced by NH125 [1].
- Properties
  - Alternative Name
    
    7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide
    
    CAS Number
    
    142557-61-7
    
    Molecular Formula
    
    C13H15N5O3
    
    Molecular Weight
    
    289.29
    
    Appearance
    
    Off-white solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

A 484954

A 484954

Background

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