Name: A 350619 hydrochloride
Price: 459.00 USD

- Overview
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    Background
    
    Km: 50 μMNitric oxide (NO) is a key mediator in many physiological processes and one of the key receptors through which NO exerts its effects is soluble guanylyl cyclase (GC). Guanylyl cyclase converts GTP to cyclic GMP that results in physiological processes such as smooth muscle relaxation, neurotransmission, platelet aggregation inhibition and immune response. A 350619 is a novel soluble guanylyl cyclase activator.In vitro: A 350619 increased Vmax from 0.1 to 14.5 μmol/min/mg, and lowered Km from 300 to 50 μM. When A 350619 and YC-1 (another GC activator) were combined, a 156 fold increase in Vmax and a 5 fold decrease in Km were observed, indicating the modulation of the enzyme brought about by YC-1 and A 350619 are not additive, indicating a common binding site. Activation of soluble guanylyl cyclase by A 350619 was partially inhibited by ODQ, a specific inhibitor of soluble guanylyl cyclase by oxidation of the enzyme heme [1]. In vivo: Consistent with its biochemical activity, in a conscious rat model, A 350619 (1 μmol/kg) alone induced penile erection. Activation of soluble guanylyl cyclase in cavernosum tissue as an alternate method of enhancing the effect of NO may provide a novel treatment of sexual dysfunction [2]. Clinical trial: Up to now, A 350619 is still in the preclinical development stage.
    
    Reference:[1] Miller LN, Nakane M, Hsieh GC, Chang R, Kolasa T, Moreland RB, Brioni JD. A 350619: a novel activator of soluble guanylyl cyclase. Life Sci. 2003 Jan 17;72(9):1015-25.
- Properties
  - Categories
    
    Activator of soluble guanylyl cyclase (sGC)
    
    Alternative Name
    
    (1Z,2E)-3-(2-((4-chlorophenyl)thio)phenyl)-N-(4-(dimethylamino)butyl)acrylimidic acid hydrochloride
    
    CAS Number
    
    1217201-17-6
    
    Molecular Formula
    
    C21H25ClN2OS·HCl
    
    Molecular Weight
    
    425.41
    
    Appearance
    
    White solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥21.25 mg/mL in DMSO; ≥13.3 mg/mL in EtOH; ≥25.7 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CN(CCCC/N=C(O)/C([H])=C([H])/C1=CC=CC=C1SC2=CC=C(Cl)C=C2)C.Cl
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

A 350619 hydrochloride

A 350619 hydrochloride

Background

Documents

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