6-Hydroxydopamine hydrobromide

- Overview
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    Background
    
    6-Hydroxydopamine hydrobromide (6-OHDA hydrobromide) is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson's disease in rodents[1].
    6-OHDA hydrobromide (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB[2].
    6-OHDA hydrobromide induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively[3].
    
    [1]. Blum D, Torch S, Lambeng N, et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson’s disease. Prog. Neurobiol, 2001, 65(2): 135-172.
    [2]. Fujita H, Ogino T, Kobuchi H, et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res, 2006, 1113(1): 10-23.
    [3]. Heuer A, Smith G A, Lelos M J, et al. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sites. Behav. Brain Res, 2012, 228(1): 30-43.
- Properties
  - Categories
    
    neurotoxin that destroys dopaminergic and noradrenergic (catecholaminergic) neurons
    
    Alternative Name
    
    5-(2-aminoethyl)benzene-1,2,4-triol hydrobromide
    
    CAS Number
    
    636-00-0
    
    Molecular Formula
    
    C8H11NO3·HBr
    
    Molecular Weight
    
    250.09
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in EtOH; ≥25 mg/mL in DMSO with ultrasonic; ≥45.4 mg/mL in H2O
    
    Storage
    
    Desiccate at -20°C
    
    SMILES
    
    OC(C(CCN)=C1)=CC(O)=C1O.Br
    
    * For Research Use Only
- Reference
  - 1. Xiaodong Wang, Yinhao Wang, et al. "Aerobic exercise improves motor function and striatal MSNs-Erk/MAPK signaling in mice with 6-OHDA-induced Parkinson's disease." Exp Brain Res. 2022 Jun;240(6):1713-1725. PMID: 35384454

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

6-Hydroxydopamine hydrobromide

Background

Documents

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