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5'-Levulinyl deoxy Thymidine CED phosphoramidite

5'-Levulinyl deoxy Thymidine CED phosphoramidite

Catalog Number:
NAS1055767CHE
Mfr. No.:
ANP-5004
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      • Overview

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      • Properties
        • Categories
          5'-Levulinyl protected Amidites
          Molecular Formula
          C24H37N4O8P
          Molecular Weight
          540.550
          Shipping
          This material is sensitive to heat and moisture. It requires the fastest shipment possible.
      • Applications
        • Application Description
          5’-O-Levulinyl DNA Phosphoramidites with Standard Base Protection:

          The levulinyl group has been employed for protection of the 5'-hydroxyl group in the synthesis of oligoribonucleotides by the phosphoramidite approach.1
          5’-O-Levulinyl DNA phosphoramidites can be used when oligonucleotide has acid labile modifications and TCA or DCA formulations cannot be used.
          Deprotection of levulinyl group can be achieved by using our levulinyl deprotection solution (Catalog # CLP7171).

          References:

          1) van Boom, J. H.; Burgers, P. M. J. Tet. Lett., 1977, 4875-4878.

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