Name: 5-Carboxytetramethylrhodamine succinimidyl ester
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- Overview
  - 5-Carboxytetramethylrhodamine succinimidyl ester is a widely employed fluorescent dye (orange/red) that is suitable for different uses. In PCR applications, it has been used as both a reporter at the 5’ or as a quencher at the 3’ end. TAMRA-labelled oligonucleotides have been used to study interactions with DNA or DNA/protein interactions. It is an excellent fluorescent acceptor for FRET applications with a suitable dye pair. It is used as a protein/antibody labelling agent for structural studies, immunochemistry and flow cytometry. Bioconjugation is generally performed through coupling of the carboxylic acid to a primary amine at the N-terminus of a protein, on lysine side chains or amino-modified oligonucleotide. Carboxylic acids that are activated with succinimidyl esters react with primary amines.
    
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- Properties
  - Categories
    
    Fine Chemicals
    
    Alternative Name
    
    5-TAMRA SE
    
    CAS Number
    
    150810-68-7
    
    Molecular Formula
    
    C29H25N3O7
    
    Molecular Weight
    
    527.52 g/mol
    
    MDL Number
    
    MFCD07366710
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Fueller., et al. (2004). Application of a Vital Fluorescent Staining Method for Simultaneous, Near-Real-Time Concentration Monitoring of Two Bacterial Strains in an Atlantic Coastal Plain Aquifer in Oyster, Virginia. Applied and environmental microbiology 70(3):1680–1687
    Hahn., et al. (2001). Influence of fluorophore dyelabels on the migration behavior of polymerase chain reaction - Amplified short tandem repeats during denaturing capillary electrophoresis. Electrophoresis 22(13): 2691-700
    Lyttle., et al. (2000). A Tetramethyl Rhodamine (Tamra) Phosphoramidite Facilitates Solid-Phase-Supported Synthesis of 5‘-TamraD. Journal of organic chemistry 65(26): 9033–9038
    Yoo., et al. (2000). Enhanced delivery of antisense oligonucleotides with fluorophore-conjugated PAMAM dendrimers. Nucleic acid Research 28(21): 4225-4231

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