4-Triazolyl Thymidine CED phosphoramidite

Convertible deoxy Amidites

C42H50N7O7P

795.860

This material is sensitive to heat and moisture. It requires the fastest shipment possible.

Summary of Modified Deoxy Amidites & Supports:

During the last couple of decades, plethora of novel structurally modified nucleic acid analogs have been introduced1 to developed probes that act as potent & selected nucleic acid based therapeutics & diagnostics2. In addition to this, these probes have also showed potential application molecular biology3 & Nanotechnology4 research and development. Incorporation of modified purines and pyrimidines has been utilized to optimize DNA-protein interactions and sequence recognition for many pro­teins and enzymes such as repressor proteins, restriction endonucleases, modification enzymes, and promoters.5,6

References:

1. Korreck. J. Eur. J. Biochem. 2003, 270, 1625.

2. Wilson, C. Curr. Opin . Chem. Biol. 2006, 5487-5502.

3. Grimm. D. Adv. Drug, Deliv. Rev. 2009, 61,672-703.

4. Lin, C. et. al. Biochemistry 2009, 48, 1663-1674.

5. Dubendorff, J. W.; de Hasett, P. L.; Rosendahl, M. S.; Caruthers, M. H. J. Biol. Chem. 1987, 262, 892.

6. Brennan, C. A.; Van Cleve, M. D.; Gumpert, R. I. J. Biol. Chem. 1986 261, 7270-7279.