Name: 4-phenyl-5-methyl-1,2,3-Thiadiazole
Price: 180.00 USD

- Overview
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    Background
    
    4-phenyl-5-methyl-1,2,3-Thiadiazole is a CYP2B4 and CYP2E1 inhibitor.Cytochrome P450 (CYP450) enzymes, a superfamily of oxidative catalysts, are important in the biosynthesis and metabolism of a wide range of endogenous molecules and the metabolism of xenobiotics. CYP2B4 can metabolize substituted amines, while CYP2E1 metabolizes various alcohols and halogenated alkenes. In vitro: 4-phenyl-5-methyl-1,2,3-Thiadiazole (PMT) was found to be slightly more inhibitory to P450s 2E1 and 1A2 than its close analog, 4,5-diphenyl-1,2,3-thiadiazole (DPT). By contrast, 4-phenyl-5-hydrogen-1,2,3-Thiadiazole (PT), a weaker inhibitor than DPT and PMT with P450s 2E1 and 2B4, was comparable to PMT and more effective than DPT with P450 1A2. Moreover, PMT, DPT, as well as PT showed no inactivation of either P450 2E1 or 2B4, though they were fairly effective inhibitors, and the thiadiazole ring could be oxidized by the P450 system. Furthremore, the lack of inactivation of the P450 isoforms by PMT, DPT, and PT suggested that a transient reactive intermediate was not formed on oxidation of the thiadiazole ring. In additioin, the 1,2,3-thiadiazole ring could be oxidized by the P450 system [1].In vivo: Up to now, there is no animla in vivo data reported.Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Alternative Name
    
    NSC 358739; 5-methyl-4-phenyl-1,2,3-thiadiazole
    
    CAS Number
    
    64273-28-5
    
    Molecular Formula
    
    C9H8N2S
    
    Molecular Weight
    
    176.2
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥10.38 mg/mL in EtOH; ≥7.85 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

4-phenyl-5-methyl-1,2,3-Thiadiazole

4-phenyl-5-methyl-1,2,3-Thiadiazole

Background

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