4-DAMP

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Background

4-DAMP is a M3 cholinergic receptor antagonist, with a Kd value of 0.5 nM for the M3 cholinergic receptor expressed in the gastric smooth muscle cell. M3 cholinergic receptors are the predominant subtype of muscarinic acetylcholine receptors, which mediates the parasympathetic control of smooth muscle contraction and glandular secretion, muscarinic acetylcholine receptor agonist-induced increases in food intake and body weight, as well as the sympathetic cholinergic control of sweating. 4-DAMP is thought to be selective for M3 receptors in peripheral tissues, but only exhibits limited selectivity for muscarinic receptors in the central nervous system.

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4. Teixeira-Neto FJ, McDonell WN, Black WD, et al. Effects of muscarinic receptor antagonists on acetylcholine-induced contractions of jejunal smooth muscle in horses. Journal of Veterinary Pharmacology and Therapeutics, 2012, 35(4): 313-318.