Name: (3S,5S)-Atorvastatin (sodium salt)
Price: 233.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Atorvastatin exists in four optical forms. The (3R, 5R)-atorvastatin enantiomer displays the greatest activity against HMG-CoA reductase. (3S,5S)-Atorvastatin is an enantiomer of atorvastatin with little or no inhibitory activity against HMG-CoA reductase [1]. Atorvastatin is a synthetic HMG-CoA reductase inhibitor implicated in lowering plasma cholesterol levels by inhibiting endogenous cholesterol synthesis. Atorvastatin also reduces triglyceride levels through an as yet unproven mechanism [2]. In various trials in patients with hypercholesterolaemia, atorvastatin produced greater reductions in total cholesterol, apolipoprotein B, LDL-cholesterol and triglyceride levels. In patients with primary hypercholesterolaemia, atorvastatin in combination with colestipol produced significant reductions in LDL-cholesterol levels and smaller reductions in triglyceride levels than atorvastatin monotherapy [2].
    
    [1] Kocarek T A, Dahn M S, Cai H, et al. Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes[J]. Drug Metabolism and Disposition, 2002, 30(12): 1400-1405.
    [2] Lea A P, McTavish D. Atorvastatin[J]. Drugs, 1997, 53(5): 828-847.
- Properties
  - Alternative Name
    
    2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, monosodium salt
    
    CAS Number
    
    1428118-38-0
    
    Molecular Formula
    
    C33H34FN2O5·Na
    
    Molecular Weight
    
    580.6
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤0.5mg/ml in ethanol;15mg/ml in DMSO;25mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

(3S,5S)-Atorvastatin (sodium salt)

(3S,5S)-Atorvastatin (sodium salt)

Background

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