3-D Life GFOGER-3 Peptide

The 3-D Life GFOGER-3 Peptide spontaneously forms stable triple helices like those in fibrillar collagens including collagen type I, II, IV and XI [1-2]. Its amino acid sequence is derived from the triple helical building block, promoting cell adhesion through integrin receptors, including α1β1 and α2β1, α10β1, and α11β1 [3]. At each end the peptide is modified with a SH-group which binds to the SH-reactive group of 3-D Life polymers. Once hydrogels are formed by crosslinking the polymers with 3-D Life crosslinkers, the immobilized peptide promotes adhesion of cells carrying the appropriate integrin receptors. GFOGER-3 mediates cell adhesion within the gel or on top of the gel. For instructions of hydrogel preparations, please consult General Protocol GP-2 “Preparation of 3-D Life Slow Gelling Hydrogels” and General Protocol GP-4 "Preparation of 3-D Life Hyaluronic Acid Hydrogels". For general information consult the 3-D Life Hydrogels User Guide.

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