2-Imino-4-methylpiperidine (acetate)

- Overview
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    Background
    
    2-Imino-4-methylpiperidine (acetate) is a potent NOS inhibitor [1] Nitric oxide (NO) is an endogenously produced inorganic free radical gas which has been implicated in endothelium-dependent vascular relaxation, cell-to-cell communication, and cytotoxicity associated with phagocytic cells. NO is synthesized by three isoforms of nitric oxide synthase (NOS): nNOS, eNOS and iNOS [1]. 2-Imino-4-methylpiperidine (acetate) is a 2-iminopiperidine class of NOS inhibitor. In the presence of a final L-arginine concentration of 30 μM, 2-Imino-4-methylpiperidine inhibited human iNOS, eNOS, and nNOS with IC50 values of 0.1, 1.1, and 0.2 μM, respectively. 2-Imino-4-methylpiperidine exhibited 9-fold and 1-fold selectivity for iNOS compared to eNOS and nNOS, respectively [1]. In LPS-treated rats, 2-Imino-4-methylpiperidine (10 mg/kg, po) inhibited plasma nitrite levels by 87%.
- Properties
  - Alternative Name
    
    3,4,5,6-tetrahydro-4-methyl-2-pyridinamine, acetate
    
    CAS Number
    
    165383-72-2
    
    Molecular Formula
    
    C6H12N2 · C2H3O2
    
    Molecular Weight
    
    171.2
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤5mg/ml in ethanol;5mg/ml in DMSO;5mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only