Name: 10-DAB (10-Deacetylbaccatin)
Price: 392.00 USD

- Overview
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    Background
    
    10-DAB (also known as 10-Deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew tree Taxus brevifolia as well as other species of the genus Taxus. Due to the low availability of taxol from its natural sources, 10-DAB is used as a raw material for the preparation of taxol and its derivatives. Being easily extracted from the annual cute of the yew leaves, 10-DAB has a very folded chemical structure with the α hydroxyl group hindered at C-13 easily to form a hydrogen bond with the 4α acetyl group.
    Reference
    F. Gueritte-Voegelein, V. Senilh, B. David, D. Guenard and P. Potier. Chemical studies of 10-deacetyl baccatin III hemisynthesis of taxol derivatives. Tetrahedron 1986; 42(16): 4451-4460
- Properties
  - Alternative Name
    
    10-Deacetylbaccatin, 10-Deacetylbaccatine III, 10-DEACETYLBACCATIN-III; (2aR,4R,4aS,6S,9S,11S,12S,12aR,12bS)-12b-acetoxy-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
    
    CAS Number
    
    32981-86-5
    
    Molecular Formula
    
    C29H36O10
    
    Molecular Weight
    
    544.59
    
    Appearance
    
    A solid
    
    Purity
    
    98.26%
    
    Solubility
    
    ≥22.25 mg/mL in DMSO; insoluble in H2O; ≥3.96 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O[[email protected]](C(C)(C)C1=C(C)[[email protected]]2O)(C2)[[email protected]]([[email protected]@H]([[email protected]@](C([[email protected]]1O)=O)(C)[[email protected]@H]3O)[[email protected]]4([[email protected]@H](C3)OC4)OC(C)=O)OC(C5=CC=CC=C5)=O
    
    * For Research Use Only
- Applications
  - Application Description
    
    Precursor of antitumor compound Palitaxel and Docetaxel