Name: ZBTB33 Polyclonal Antibody
Price: 253.00 USD

Overview
- Gene Accession: NP006768
  
  Please contact us at for specific academic pricing.
  
  Background
  
  This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Synthetic peptide of human ZBTB33
  
  Purification
  
  Antigen affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  0.9 mg/mL
  
  Antigen
  
  Kaiso, Kaiso protein, Kaiso transcription factor, KAISO, Transcriptional regulator Kaiso, ZBTB 33, Zbtb33, Zinc finger and BTB domain containing 33, Zinc finger and BTB domain-containing protein 33, Zinc finger transcription factor Kaiso, ZNF 348, ZNF Kaiso, ZNF348 (UniProt:Q86T24)
  
  * For reference only.