Name: Wnt agonist 1
Price: 175.00 USD

- Overview
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    Background
    
    Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway [1].
    The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation [1].
    Wnt agonist 1 is a cell-permeable Wnt signaling pathway agonist. Wnt agonist 1 induced b-catenin- and TCF-dependent transcriptional activity in a dose-dependent way with EC50 of 0.7 μM. In Xenopus embryos, treatment with Wnt agonist 1 (10 μM) from developmental stage 10.5 to stage 40 resulted in substantial head defects, such as diminished heads and complete loss of eyes, and reduced eyes and heads. This phenotype is similar to that which results from Wnt over-expression in head specification during early embryonic development.
- Properties
  - Categories
    
    agonist of Wnt signaling pathway
    
    Alternative Name
    
    BML-284; (Z)-1-(benzo[d][1,3]dioxol-5-yl)-N-(2-imino-6-(3-methoxyphenyl)-2,3-dihydropyrimidin-4(1H)-ylidene)methanamine hydrochloride
    
    CAS Number
    
    853220-52-7
    
    Molecular Formula
    
    C19H19ClN4O3
    
    Molecular Weight
    
    386.83
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥38.7 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    COC1=CC=CC(C(NC2=N)=C/C(N2)=N/CC3=CC4=C(OCO4)C=C3)=C1.Cl
    
    * For Research Use Only
- Reference
  - 1. Wenwen Liu, Yang Zhou, et al. "Glutathione peroxidase 4-dependent glutathione high-consumption drives acquired platinum chemoresistance in lung cancer-derived brain metastasis." Clin Transl Med. 2021 Sep;11(9):e517. PMID:34586745
    2. Yang JM, Huang HM, et al. "LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway."Toxicology. 2018 Sep 8;410:65-72. PMID:30205152