VRK1 Polyclonal Antibody

VRK1 Polyclonal Antibody

Catalog Number:
A001507989RED
Mfr. No.:
RD252422A
Price:
$253
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      • Overview
        • Calculated MW: 45 kDa
          Observed MW: Refer to figures
          Gene Accession: BC113510

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          Background

          This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse
          Immunogen
          Fusion protein of human VRK1
          Purification
          Antigen affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
          Storage
          Store at -20°C. Avoid freeze-thaw cycles.
          Concentration
          0.5 mg/mL
          Antigen
          MGC117401, MGC138280, MGC142070, PCH1, PCH1A, Serine/threonine protein kinase VRK1, Serine/threonine-protein kinase VRK1, Vaccinia related kinase 1 , Vaccinia virus B1R related kinase 1, Vaccinia-related kinase 1, VRK1, VRK1 (UniProt:Q99986)

          * For reference only.

      • Applications
        • Application
          WB; IHC; ELISA
        • Application Dilutions
          WB 1:500-1:2000
          IHC 1:25-1:100
          ELISA 1:5000-1:10000

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