VRK1, Dominant Negative Adenovirus (Ready-to-package) C-terminus 6xHN tag

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    The strong conservation of the kinase domain among kinome members allows the identification of key amino acids required for the activity of these enzymes. Mutations of one or two conserved lysine residues in the ATP-binding pocket and/or the substrate binding pocket completely abolish the activity of these kinases but do not interfere with substrate recognition or binding to other proteins. Thus, kinase proteins can be modified to generate kinase-dead mutants that are not enzymatically active but have a dominant-negative effect in sequestering the activity of the substrate/interactor, resulting in a loss of function phenotype. The dominant negative effects of kinase-death variants are mediated through interactions between the inactive variant and the effector protein.
- Properties
  - Categories
    
    Ready-to-package Adenoviruses
    
    Alternative Name
    
    Vaccinia Related Kinase 1 (kinase dead or dominant negative), cloned into the Ad - MAX™ adenovirus expression system, ready to package
    
    Other Properties
    
    Titer: 1E+10 ~ 1E+11 PFU/mL
    Promoter: CMV
    Storage Buffer: DMEM with 2.5% BSA, 2.5% glycerol
    Gene Name: Vaccinia Related Kinase 1 (kinase dead or dominant negative)
    NCBI Accession Number: NM_003384
    Gene Symbol: VRK1
    Gene ID: 7443
    GI Number: 4507902
    Fusion Tag: C-terminus 6xHN tag
    
    Note
    
    The default promoter of our adenoviruses is CMV with a standard size of 0.2 ml (1E+10 to 1E+11 PFU/ml). Larger packaged adenovirus vectors with different promoters (CAG, U6, H1, UBC or Synapsin), and reporters (GFP, mRFP, Luc, LacZ, etc.) can be customized.
    
    * This product is for laboratory research ONLY and not for diagnostic use.

VRK1, Dominant Negative Adenovirus (Ready-to-package) C-terminus 6xHN tag

VRK1, Dominant Negative Adenovirus (Ready-to-package) C-terminus 6xHN tag

Background

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