Name: VEGFA Polyclonal Antibody (1.8 mg/mL) for WB, IHC, ELISA
Price: 253.00 USD

Overview
- Calculated MW: 27 kDa
  Observed MW: Refer to figures
  Gene Accession: NP001020537
  
  Please contact us at for specific academic pricing.
  
  Background
  
  This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Synthetic peptide of human VEGFA
  
  Purification
  
  Antigen affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  1.8 mg/mL
  
  Antigen
  
  Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, MGC70609, MVCD1, Vascular endothelial growth factor A, vascular endothelial growth factor A121, vascular endothelial growth factor A165, vascular endothelial growth factor, Vascular permeability factor, VEGF A, Vegf, VEGF-A, VEGF120, Vegfa, VEGFA, VPF (UniProt:P15692)
  
  * For reference only.

Applications

Application

WB; IHC; ELISA

Application	Dilutions
WB	1:1000-1:5000
IHC	1:30-1:150
ELISA	1:5000-1:10000

VEGFA Polyclonal Antibody (1.8 mg/mL) for WB, IHC, ELISA

VEGFA Polyclonal Antibody (1.8 mg/mL) for WB, IHC, ELISA

Background

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