Ubiquitin Conjugating Enzyme E2 A/B Rabbit Polyclonal Antibody

Ubiquitin Conjugating Enzyme E2 A/B Rabbit Polyclonal Antibody

Catalog Number:
A001453580ZEN
Mfr. No.:
Zen-251491
Price:
  • Size:
    100μl
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      • Overview
        • Please contact us at for specific academic pricing.

          Background

          Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation.

      • Properties
        • Host
          rabbit
          Isotype
          IgG
          Reactivity
          human; mouse; rat
          Immunogen
          Synthesized peptide derived from the C-terminal region of human UBE2A/B.
          Purification
          Affinity Purified
          Conjugate
          Unconjugated
          Formulation
          Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
          Storage
          Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
          Molecular Weight
          Calculated MW: 17 kDa; Observed MW: 17 kDa
          Antigen
          (Gene ID:7319/7320; UniProt:P49459/P63146)

          * Research Use Only Product (RUO). Not for Diagnosis or Therapeutic Use.

      • Applications
        • Application
          WB; IHC-P; ELISA
        • Application Dilutions
          WB 1/500-1/1000
          IHC 1/50-1/100
          ELISA 1/10000

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