Tocilizumab Biosimilar - Research Grade, Low Endotoxin

Tocilizumab Biosimilar - Research Grade, Low Endotoxin

Catalog Number:
A001437362ICH
Mfr. No.:
ICH4012
Price:
$1,404
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      • Overview
        • Specificity: Detects human IL-6 receptor. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Tocilizumab.
          Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
          Isotype Control: Bulk Human IgG1 Isotype Control (IB1) [ICH2254]
          Endotoxin: ≤ 0.75 EU/mg as determined by the LAL method

          Please contact us at for specific academic pricing.

          Background

          Tocilizumab is a recombinant humanized anti-human interleukin 6 (IL-6) receptor monoclonal antibody of the immunoglobulin IgG1κ (gamma 1, kappa) subclass with a typical H2L2 polypeptide structure. Each light chain and heavy chain consists of 214 and 448 amino acids, respectively. The four polypeptide chains are linked intra- and inter-molecularly by disulfide bonds. Tocilizumab has a molecular weight of approximately 148 kDa. The antibody is produced in mammalian (Chinese hamster ovary) cells.

      • Properties
        • Host
          humanized
          Isotype
          IgG1 kappa
          Reactivity
          human
          Purification
          >95% by SDS-PAGE and HPLC
          Formulation
          Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free.
          Storage
          Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
          Molecular Weight
          1.0 - 5.0 mg/ml
          Antigen
          (Gene ID:IL6R)

          * Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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