Name: TATA Box Binding Protein Mouse Monoclonal Antibody
Price: Inquiry

Overview
- Please contact us at for specific academic pricing.
  
  Background
  
  Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
Properties
- Host
  
  mouse
  
  Isotype
  
  Mouse IgG1
  
  Reactivity
  
  human
  
  Immunogen
  
  Purified recombinant fragment of human TBP expressed in E. Coli.
  
  Purification
  
  Affinity Purified
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody in PBS with 0.05% sodium azide
  
  Storage
  
  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  
  Molecular Weight
  
  Calculated MW: 38 kDa
  
  Antigen
  
  (Gene ID:6908; UniProt:P20226)
  
  * Research Use Only Product (RUO). Not for Diagnosis or Therapeutic Use.

Applications

Application

WB; IHC-P; ICC/IF; FC; ELISA

Application	Dilutions
WB	1/500-1/1000
IHC	1/100-1/200
IF	1/50-1/200
FC	1/50-1/100
ELISA	1/10000

TATA Box Binding Protein Mouse Monoclonal Antibody

TATA Box Binding Protein Mouse Monoclonal Antibody

Background

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