SST2 ( IHC-grade ), Somatostatin Receptor 2 Polyclonal Antibody

Overview
- The SST2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human Somatostatin Receptor 2. It detects selectively the canonical form of SST2 (also referred to as SST2A) and not the putative splice variant SST2B. In can be used to detect total SST2 receptors in Western blots independent of phosphorylation. The SST2 antibody can also be used to isolate and enrich SST2 receptors from tissue lysates. It also detects SST2 in cultured cells and tissue sections by immunohistochemistry. The SST2 antibody has been validated using knockout mice (KO-Validated).
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  A synthetic peptide corresponding to residues 335–369 of human, mouse and rat SST2
  
  Purification
  
  Antigen affinity chromatography
  
  Formulation
  
  Liquid
  
  Storage
  
  Short-term storage at 4°C and long-term storage at -20°C
  
  Antigen
  
  SST2, SSTR2, Somatostatin Receptor 2 (UniProt:P30874 (human), P30875 (mouse), P30680 (rat))
  
  * This product is intended for research use only.

Applications

Application

WB; ICC; IHC

Application	Dilutions
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	1:200
Immunohistochemistry (IHC)	1:100

Reference
- Schulz S, Pauli SU, Schulz S, Händel M, Dietzmann K, Firsching R, Höllt V. Immunohistochemical determination of five somatostatin receptors in meningioma reveals frequent overexpression of somatostatin receptor subtype sst2A. Clin Cancer Res. 2000 May;6(5):1865-74.
  Asnacios A, Courbon F, Rochaix P, Bauvin E, Cances-Lauwers V, Susini C, Schulz S, Boneu A, Guimbaud R, Buscail L. Indium-111-pentetreotide scintigraphy and somatostatin receptor subtype 2 expression: new prognostic factors for malignant well-differentiated endocrine tumors. J Clin Oncol. 2008 Feb 20;26(6):963-70. doi: 10.1200/JCO.2007.12.7431.
  Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. J Clin Endocrinol Metab. 2008 Nov;93(11):4519-24. doi: 10.1210/jc.2008-1063. Epub 2008 Aug 12.
  Lesche S, Lehmann D, Nagel F, Schmid HA, Schulz S. Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro. J Clin Endocrinol Metab. 2009 Feb;94(2):654-61. doi: 10.1210/jc.2008-1919. Epub 2008 Nov 11.
  Shi TJ, Xiang Q, Zhang MD, Barde S, Kai-Larsen Y, Fried K, Josephson A, Glück L, Deyev SM, Zvyagin AV, Schulz S, Hökfelt T. Somatostatin and its 2A receptor in dorsal root ganglia and dorsal horn of mouse and human: expression, trafficking and possible role in pain. Mol Pain. 2014 Feb 13;10:12. doi: 10.1186/1744-8069-10-12. PubMed PMID: 24521084; PubMed Central PMCID: PMC3943448.

SST2 ( IHC-grade ), Somatostatin Receptor 2 Polyclonal Antibody

SST2 ( IHC-grade ), Somatostatin Receptor 2 Polyclonal Antibody

We Also Recommend

B2 ( IHC-grade ), Bradykinin Receptor 2 Polyclonal Antibody

CRF1 ( IHC-grade ), Corticotropin-Releasing Factor Receptor 1 Polyclonal Antibody

NK1 ( IHC-grade ), Tachykinin Receptor 1 Receptor Polyclonal Antibody