Name: SensiStain™ Anti-CMTM6 Antibody
Price: 383.00 USD

Overview
- CMTM6, also referred to as CKLF Like MARVEL Transmembrane Domain Containing 6, is widely expressed in many tissues, but the function relatively remains unknown. SensiStain™ Anti- CMTM6 Antibody detects the presence of CMTM6 which can be found binding to PD-L1 and maintains its cell surface expression. Studies have showed that due to the binding to PD-L1, CMTM6 co-localizes at plasma membrane and recycling endosomes preventing PD-L1 from being targeted for lysosome-mediated degradation. Due to the high specificity CMTM6 has with PD-L1, it can be studied alongside with PD-L1 as it has a role in suppression of tumour-specific T cell activity.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human
  
  Clone
  
  ACH0275
  
  Immunogen
  
  Recombinant Human PD-L1
  
  Purification
  
  Protein A/G Affinity Purified
  
  Formulation
  
  Liquid
  
  Storage
  
  This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
  
  Concentration
  
  100 μg/ 100 μl
  
  * This product is only for laboratory research and not for diagnostic use.

Applications

Application	Dilutions
IHC	1:1000-1:3000
ELISA	1:1000-1:2000 (Optimal dilutions or concentrations should be determined by the end user)

Reference
- Gao, F., Chen, J., Wang, J., Li, P., Wu, S., Wang, J., & Ji, Y. "CMTM6, the newly identified PD-L1 regulator, correlates with PD-L1 expression in lung cancers" Biochemistry and biophysics reports 20:100690 (2019).
  Shi, P., Su, Y., Li, R., Liang, Z., Dong, S., & Huang, J. "PEDV nsp16 negatively regulates innate immunity to promote viral proliferation" Virus Research 265:57–66 (2019). DOI: 10.1016/j.virusres.2019.03.005.
  Shi, P., Su, Y., Li, R., Zhang, L., Chen, C., Zhang, L., … Huang, J. "Dual Regulation of Host TRAIP Post-translation and Nuclear/Plasma Distribution by Porcine Reproductive and Respiratory Syndrome Virus Non-structural Protein 1α Promotes Viral Proliferation" Frontiers in Immunology 9: (2018). DOI: 10.3389/fimmu.2018.03023.

SensiStain™ Anti-CMTM6 Antibody