SDHB Mouse Monoclonal Antibody

SDHB Mouse Monoclonal Antibody

Catalog Number:
A001452912ZEN
Mfr. No.:
Zen-222721
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      • Overview
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          Background

          Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

      • Properties
        • Host
          mouse
          Isotype
          Mouse IgG1
          Reactivity
          human
          Immunogen
          Purified recombinant fragment of human SDHB expressed in E. Coli.
          Purification
          Affinity Purified
          Conjugate
          Unconjugated
          Formulation
          Purified antibody in PBS with 0.05% sodium azide
          Storage
          Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
          Antigen
          (Gene ID:6390; UniProt:P21912)

          * Research Use Only Product (RUO). Not for Diagnosis or Therapeutic Use.

      • Applications
        • Application
          IHC-P; FC; ELISA
        • Application Dilutions
          IHC 1/100-1/200
          FC 1/50-1/100
          ELISA 1/10000

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