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Overview
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Background
Ribosomal Protein L22 is also known as heparin-binding protein HBp15, because it binds heparin in the submandibular gland and brain. This small protein is also associated with two small nuclear RNAs called EBERs (Epstein- Barr encoded RNAs). These RNAs are synthesized in large amounts by human B lymphocytes infected with Epstein-Barr virus (EBV). Ribosomal protein L22, like L4, contains a globular domain that sits on the surface of the large ribosomal subunit and an extended loop that penetrates its core. These extensions contact multiple domains of 23S rRNA, indicating a potential, but not essential, role in rRNA folding during ribosomal assembly.
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