Name: RGD (Arg-Gly-Asp) Peptides
Price: 263.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Synthetic peptides containing the arginine-glycine-aspartate (RGD) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the RGD motif is an integrin-recognition motif found in many ligands.
    In vitro: RGD peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Previous study demonstrates that RGD peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].
    In vivo: Anima study suggested that the RGD-4C-FITC-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].
    Clinical trials: Currenlty no clinical data are available.
    
    [1] Nature. 1999 Feb 11;397(6719):534-9.RGD peptides induce apoptosis by direct caspase-3 activation. Buckley CD1, Pilling D, Henriquez NV, Parsonage G, Threlfall K, Scheel-Toellner D, Simmons DL, Akbar AN, Lord JM, Salmon M.
    [2] Cancer Res. 2002 Sep 15;62(18):5139-43. Arginine-glycine-aspartic acid (RGD)-peptide binds to both tumor and tumor-endothelial cells in vivo. Zitzmann S1, Ehemann V, Schwab M.
- Properties
  - CAS Number
    
    99896-85-2
    
    Molecular Formula
    
    C12H22N6O6
    
    Molecular Weight
    
    346.34
    
    Appearance
    
    A solid
    
    Purity
    
    99.92%
    
    Solubility
    
    insoluble in DMSO; insoluble in EtOH; ≥17.3 mg/mL in H2O with gentle warming
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

RGD (Arg-Gly-Asp) Peptides

RGD (Arg-Gly-Asp) Peptides

Background

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