Recombinant XBP1 Monoclonal Antibody

Recombinant XBP1 Monoclonal Antibody

Catalog Number:
A001512081RED
Mfr. No.:
RD87095A
Price:
$392
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      • Overview
        • Calculated MW: 45kDa
          Observed MW: 65kDa

          Please contact us at for specific academic pricing.

          Background

          This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.

      • Properties
        • Host
          rabbit
          Antibody Type
          monoclonal
          Isotype
          IgG
          Reactivity
          human; mouse
          Immunogen
          Recombinant protein of human XBP1
          Purification
          Affinity purification
          Conjugate
          Unconjugated
          Formulation
          50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
          Storage
          Store at -20°C Valid for 12 months. Avoid freeze-thaw cycles.
          Concentration
          300 μg/mL
          Antigen
          Tax responsive element binding protein 5, Tax-responsive element-binding protein 5, TREB5, X box binding protein 1, X box binding protein 2, X-box-binding protein 1, XBP 1, XBP-1, XBP1, XBP1, XBP2 (Gene ID:7494; UniProt:P17861)

          * For reference only.

      • Applications
        • Application
          WB
        • Application Dilutions
          WB 1:500-1:1000

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