Name: Recombinant SARS-CoV-2 Nucleocapsid Protein full length, His-tagged (PODTC9) NC_045512.2, 100µg
Price: 969.00 USD

- Overview
  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-strand RNA virus that causes the disease COVID-19 (Coronavirus Disease-2019). The COVID-19 pandemic is a global problem among the world's population. The diagnosis is difficult due to its unspecific symptoms. In this context, rapid and easy to implement diagnostic tools are urgently needed.
    SARS-CoV-2 has four major structural proteins, including nucleocapsid (N), spike (S), membrane (M), and small envelope (E). The N protein is the only one that binds to the RNA genome and is also involved in viral assembly and budding. The SARS-CoV-2 N is a highly immunogenic multi-functional protein that can be divided into five domains: a predicted intrinsically disordered N-terminal domain (NTD), an RNA-binding domain (RBD), a predicted disordered central linker (LINK), a dimerization domain, and a predicted disordered C-terminal domain (CTD).
    Detection of viral antigens can be a possible strategy to get an early diagnosis of SARS-CoV-2 infection. The nucleocapsid protein (NP) has been confirmed as the ideal target for the early detection of SARS-CoV infection, which is genetically similar to SARS-CoV-2, so that it could be detected up to 1 day before the appearance of clinical symptoms.
    
    Recombinant SARS-CoV-2 Nucleocapsid protein is expressed in E.coli cells. The protein consists of 419 amino acids and an N-terminal His6-tag. The calculated Molecular Weight range of the His-tagged protein is 46.5 kDa. The protein is solubilized in 25 mM Na- Phosphat 6.8, 250 mM NaCl, 2 mM ß-Mercaptoethanol.
    
    Please contact us at for specific academic pricing.
- Properties
  - Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    More than 90% of total protein
    
    Formulation
    
    The protein is solubilized in 25 mM Na-Phosphat 6.8, 250 mM NaCl, 2 mM ß-Mercaptoethanol.
    
    Storage
    
    The protein is stable until the expiry date given on the label when stored at -70 °C. The protein can be kept at -20 °C for several weeks and on ice for several days. Repeated freezing and thawing should be avoided.
    
    Molecular Weight
    
    46.5 kDa
    
    * For Research Use Only
- Applications
  - Application Description
    
    Expression of full-length or fragments of N protein in soluble form and relatively large quantity is desirable for study of viral invasion, construction of diagnostic kits (being one of the predominantly expressed proteins at the early stage of SARS-CoV infection) and potential application as subunit vaccines.

Datasheet

Recombinant SARS-CoV-2 Nucleocapsid Protein full length, His-tagged (PODTC9) NC_045512.2, 100µg

Recombinant SARS-CoV-2 Nucleocapsid Protein full length, His-tagged (PODTC9) NC_045512.2, 100µg

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