Recombinant Mouse Lymphotoxin beta Receptor/LTBR/TNFRSF3/TNFRrp (C-Fc)

Recombinant Mouse Lymphotoxin beta Receptor/LTBR/TNFRSF3/TNFRrp (C-Fc)

Catalog Number:
P001411534ABE
Mfr. No.:
Abe32-9724
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      • Overview
        • It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoter activity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondary lymphoid organs and chemokine release.

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      • Properties
        • Protein Name
          Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor, Ltbr, Tnfcr, Tnfrsf3
          Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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