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Recombinant Mouse HIPK2 (N-GST tag)

Recombinant Mouse HIPK2 (N-GST tag)

Catalog Number:

E001278618APP

Mfr. No.:

Z600013

Price:

$672

Size:

10 µg

Quantity:

Add to Cart:

- Overview
  - HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors. HIPK2 enhances expression of p53 target genes that resulting in growth arrest and the enhancement of UV-induced apoptosis that could be inhibited by antisense to HIPK2. HIPK2 as a target for MDM2 mediated ubiquitin-dependent degradation that only occurred in growth-arresting conditions when MDM2 was efficiently induced by p53. The knockdown of HIPK2 using small interfering RNA reduced p53 binding and activation of p53R2 that resulting in impaired UV-induced DNA repair.
    
    Please contact us at for specific academic pricing.
- Properties
  - Name
    
    Stank; 1110014O20Rik; B230339E18Rik
    
    Source
    
    Insect cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
    
    Storage
    
    Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
    
    Molecular Weight
    
    72.0 kDa
    
    Class
    
    Active Kinases
    
    * For research use only. Not for diagnostic or therapeutic use.

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