Name: Recombinant Mouse Endothelial Cell-Specific Molecule /Endocan/ESM-1 (C-6His)
Price: Inquiry

- Overview
  - MW : 19kD. Recombinant Mouse ESM-1 is produced by our Mammalian expression system and the target gene encoding Trp20-Arg184 is expressed with a 6His tag at the C-terminus. Endothelial cell-specific molecule1 (ESM-1)so-called endocanis a novel endothelium derived soluble dermatan sulfate proteoglycan (PG) that is constitutively expressed by endothelial cells in lungs and kidneys and can be detected in human blood. It is encoded by the ESM1 gene. The expression of this gene is regulated by several cytokines and growth factors, such as vascular endothelial growth factor. Inflammatory cytokines, such as interleukin (IL)-1 beta and tumor necrosis factor (TNF)-a, stimulate the upregulation of endocan mRNA and the secretion of endocan from endothelial cells. The binding of circulating endocan to leukocyte ligand for ICAM-1Lymphocyte Function-associated Antigen-1 (LFA-1) and to leukocyte ligand for VCAM-1Very Late Antigen-4 (VLA-4) is important in leukocyte adhesion and interaction with activated endothelium. Endocan is a key player in the regulation of major processes such as cell adhesion in inflammatory disorders and tumor progression.
    
    Please contact us at for specific academic pricing.
- Properties
  - Source
    
    Human cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
    
    Storage
    
    Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.
    
    Endotoxin
    
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
    
    More Information
    
    UniProt
    
    Q9QYY7
    
    Gene ID
    
    71690
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Mouse Endothelial Cell-Specific Molecule /Endocan/ESM-1 (C-6His)

Recombinant Mouse Endothelial Cell-Specific Molecule /Endocan/ESM-1 (C-6His)

More Information

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