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Recombinant Human ZAK (N-GST tag)

Recombinant Human ZAK (N-GST tag)

Catalog Number:

E001278612APP

Mfr. No.:

Z500411

Price:

$672

Size:

10 µg

Quantity:

Add to Cart:

- Overview
  - ZAK is a member of the MAPKKK family of signal transduction molecules and mediates gamma radiation signaling leading to cell cycle arrest. The activity of ZAK plays a role in cell cycle checkpoint regulation as well as being involved in regulating actin organization. Expression of kinase-dead ZAK in mouse fibroblasts disrupts actin stress fibers and causes morphologic changes. ZAK can activate JNK through MKK4/MKK7 and ERK5/p38-gamma via MKK3/MKK6. Expression of ZAK increases the population of cells in the G2/M phase of the cell cycle, whereas dominant-negative ZAK attenuated the G2 arrest caused by gamma radiation.
    
    Please contact us at for specific academic pricing.
- Properties
  - Name
    
    AZK, MLT, MRK, MLK7, MLTK, mlklak
    
    Source
    
    Insect cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
    
    Storage
    
    Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
    
    Molecular Weight
    
    82.0 kDa
    
    Class
    
    Active Kinases
    
    * For research use only. Not for diagnostic or therapeutic use.

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