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Recombinant Human ULK2 (N-GST tag)

Recombinant Human ULK2 (N-GST tag)

Catalog Number:
E001278598APP
Mfr. No.:
Z500403
Price:
$768
  • Size:
    10 µg
    Quantity:
    Add to Cart:
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      • Overview

        • ULK2 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. Mammalian Atg13 binds ULK2 and mediates the interaction of the ULK protein with FIP200. The binding of Atg13 stabilizes and activates ULK and facilitates the phosphorylation of FIP200 by ULK. The ULK-Atg13-FIP200 complex is a direct target of mTOR and important regulator of autophagy in response to mTOR signalling. Yeast 2-hybrid assays showed the C-terminus of ULK2 binds the C-terminus of SynGAP, a negative regulator of Ras that is associated with neural development.

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      • Properties
        • Name
          Unc51.2, KIAA0623
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          98.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

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