Login / Register
0

Recombinant Human TIE2 (N-GST tag)

Recombinant Human TIE2 (N-GST tag)

Catalog Number:
E001278574APP
Mfr. No.:
Z500387
Price:
$672
  • Size:
    10 µg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • TIE 2 or TEK is a receptor tyrosine kinase that is expressed principally on vascular endothelium. Disrupting TIE 2 function in mice results in embryonic lethality with defects in embryonic vasculature, suggesting a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TIE 2 receptor tyrosine kinase. SHP2 and GRB2 are recruited to the activated TIE 2 kinase domain and are part of the cellular responses that mediate TIE 2 function. TIE 2 expression is upregulated in the endothelium of vascular "hot spots" in human breast cancer specimens. However, TIE 2 is also overexpressed in areas of active angiogenesis in normal tissues.

          Please contact us at for specific academic pricing.

      • Properties
        • Name
          TEK, VMCM, VMCM1, CD202B
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          61.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

    We Also Recommend

    Recombinant Human TESK2 (N-GST tag)

    Recombinant Human TESK2 (N-GST tag)

    $672

    Recombinant Human TGFBR1 (ALK5) (N-GST tag)

    Recombinant Human TGFBR1 (ALK5) (N-GST tag)

    $672

    Recombinant Human TGFBR2 (N-GST tag)

    Recombinant Human TGFBR2 (N-GST tag)

    $672

    Note: If you don't receive our verification email, do the following:

    Products
    Amerigo Scientific
    Support
    Contact Us
    Copyright © Amerigo Scientific. All rights reserved.