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Overview
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Syndecan-1, also known as SDC1 and CD138, is a transmembrane heparan sulfate proteoglycan that belongs to the syndecan proteoglycan family. It is expressed mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1 has been found to regulate cell adhesion to several ECM molecules, and to play as a co-receptor for fibroblast growth factors, potent angiogenic growth factors involved in differentiation. The expression level of Syndecan-1 is reduced during malignant transformation of various epithelia, and this loss associates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumors. Studies showed in squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a better prognosis.
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