Name: Recombinant Human Serpin Peptidase Inhibitor, Clade I Member 1
Price: Inquiry

- Overview
  - SERPINI1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 395 amino acids and having a total molecular mass of 44.6kDa. SERPINI1 is purified by proprietary chromatographic techniques. SERPINI1 (Neuroserpin) is an inhibitory serpin which is expressed primarily in the central nervous system. Even though the physiological target of SERPINI1 is still vague, amassed evidence suggest that SERPINI1 has an imperative role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis and the subsequent development of neuronal plasticity. The neuroprotective role of SERPINI1 has been demonstrated in transgenic mice lacking SERPINI1 expression. The deficiency of SERPINI1 in these mice is linked with motor neuron disease characterized by axonal degradation. In humans, defects in SERPINI1, caused by point mutations in the neuroserpin gene, trigger a hereditary disorder known as the familial encephalopathy with neuroserpin inclusion bodies (FENIB).
    
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- Properties
  - Protein Name
    
    Neuroserpin, Peptidase inhibitor 12, PI-12, Serpin I1, SERPINI1, PI12.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 97.0% as determined by (a) Analysis by HPLC. (b) Analysis by SDS-PAGE.
    
    Formulation
    
    The protein was Lyophilized from a 0.2µm filtered concentrated solution in 1xPBS, pH 7.4.
    
    Storage
    
    Lyophilized SERPINI1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution SERPINI1 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.
- Applications
  - Application Description
    
    It is recommended to reconstitute the lyophilized SERPINI1 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. Determined by the dose-dependent stimulation of the proliferation of rat C6 cells using a concentration range of 0.3-0.6 μg/ml.

Recombinant Human Serpin Peptidase Inhibitor, Clade I Member 1

Recombinant Human Serpin Peptidase Inhibitor, Clade I Member 1

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