Recombinant Human s-COMT V158M, His-tagged

- Overview
  - Recombinant human s-COMT/Natural Variant 108/158 Val->Met (51-271) is produced in E. coli. The protein consists of amino acids M51-P271 of MB-COMT (membrane bound) and a C-terminal His6-tag. Recombinant s-COMT V158M is used to study the elimination of biologically active or toxic catechols and some other hydroxylated metabolites. It acts as detoxicating barrier between blood and other tissues. COMT activity may regulated the amounts of dopamine and norepinephrine in various parts of the brain and therefore be associated with mood and other metal processes. The enzyme can also serve as standard in enzymatic and immunochemical assays.
    
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- Properties
  - Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    More than 95% of total protein
    
    Formulation
    
    COMT is solublized in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl₂.
    
    Storage
    
    Recombinant s-COMT-108/158-Natural Variant is stable until the expiry date given on the label when stored at -70 °C. The enzyme can be kept at -20 °C for several weeks. Repeated freezing and thawing should be avoided.
    
    Molecular Weight
    
    24.5 kDa
    
    * For Research Use Only
- Applications
  - Application Description
    
    Recombinant s-COMT is used to study the elimination of biologicaly active or toxic catechols and some other hydroxylated metabolites. It acts as detoxicating barrier between blood and other tissues. COMT activity may regulated the amounts of dopamine and norepinephrine in various parts of the brain and therefore be associated with mood and other metal processes. The enzyme can also serve as standard in enzymatic and immunochemical assays.

Datasheet

Recombinant Human s-COMT V158M, His-tagged

Recombinant Human s-COMT V158M, His-tagged

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