Name: Recombinant Human RING1 & YY1 Binding Protein
Price: Inquiry

- Overview
  - RYBP Human Recombinant produced in E. coli is a single polypeptide chain containing 252 amino acids (1-228) and having a molecular mass of 27.4 kDa. RYBP is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. RING1- and YY1-binding protein (RYBP) belongs to the polycomb group (PcG). RYBP interacts with MDM2 and decreases MDM2-mediated p53 ubiquitination, which leads to stabilization of p53 and an increase in p53 activity. RYBP causes cell-cycle arrest and is involved in the p53 response to DNA damage. RYBP interacts with RING1, YY1, Caspase 10, E2F3, E2F2, Mdm2, Abl gene and CBX2. RYBP inhibits ubiquitination and subsequent degradation of TP53, and thus has a role in regulating transcription of TP53 target genes. RYBP may also be involved in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. RYBP may bind to DNA, and promote apoptosis.
    
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- Properties
  - Protein Name
    
    RING1 and YY1 binding protein, Death effector domain-associated factor, Apoptin-associating protein 1, YY1 and E4TF1-associated factor 1, ring1 interactor RYBP, DED-associated factor, APAP-1, DEDAF, YEAF1.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 85% as determined by SDS-PAGE.
    
    Formulation
    
    The RYBP solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 20% glycerol.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human RING1 & YY1 Binding Protein

Recombinant Human RING1 & YY1 Binding Protein

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