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Overview
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Prostaglandin-H2 D-Isomerase (PTGDS) is an enzyme that belongs to the lipocalin family of calycin superfamily. PTGDS is preferentially expressed in the brain. It catalyzes the conversion of Prostaglandin H2 (PGH2) to Prostaglandin D2 (PGD2), a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS takes part in various CNS functions, such as sedation, REM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. PTGDS is used clinically as a diagnostic marker for Cerebrospinal fluid rhinorrhea, important in the assessment of head trauma severity. It has been predicted that the urinary and serum levels pf PTGDS may be also a marker of renal damage in diabetes mellitus and hypertension.
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