Name: Recombinant human PD-L1 protein with C-terminal 6×His tag
Price: Inquiry

- Overview
  - The protein has a predicted molecular mass of 26.0 kDa after removal of the signal peptide. The apparent molecular mass of PDL1-His is approximately 33-35 kDa due to glycosylation. This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
    
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- Properties
  - Protein Name
    
    PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1
    
    Source
    
    HEK293 cells
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
    
    Formulation
    
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    
    Storage
    
    Store at -80°C for 12 months (Avoid repeated freezing and thawing)
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Human PD-L1 Protein, His Tag on SDS-PAGE under reducing condition.

Recombinant human PD-L1 protein with C-terminal 6×His tag

Recombinant human PD-L1 protein with C-terminal 6×His tag

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