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Overview
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The protein has a predicted molecular mass of 44.0 kDa after removal of the signal peptide. This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogrens syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
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Overview