Name: Recombinant Human Nucleic Acid Binding Protein 1
Price: Inquiry

- Overview
  - NABP1 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 227 amino acids (1-204 a.a) and having a molecular mass of 24.8kDa. NABP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Nucleic acid binding protein 1 is a part of the SOSS complex, a multiprotein complex which functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, NABP1 acts as a sensor of single-stranded DNA which binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex links with DNA lesions and affects diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. NABP1 is essential for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
    
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- Properties
  - Protein Name
    
    Nucleic Acid Binding Protein 1, OBFC2A, Sensor OfSingle-Strand DNA Complex Subunit B2, Single-Stranded DNA-Binding Protein 2, SSB2, Oligonucleotide/Oligosaccharide-Binding Fold Containing 2A, NucleicAcid-Binding Protein 1, Oligonucleotide/Oligosacc
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 95.0% as determined by SDS-PAGE.
    
    Formulation
    
    NABP1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) 0.2M, NaCl, 50% glycerol and 2mM DTT.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Nucleic Acid Binding Protein 1

Recombinant Human Nucleic Acid Binding Protein 1

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