Name: Recombinant Human NEDD8-Conjugating Enzyme UBC12/UBE2M
Price: Inquiry

- Overview
  - MW : 20.9kD. Recombinant Human Ubiquitin-conjugating Enzyme E2M is produced by our E.coli expression system and the target gene encoding Met1-Lys183 is expressed. UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. UBE2M accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. It involved in cell proliferation and is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
    
    Please contact us at for specific academic pricing.
- Properties
  - Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Supplied as a 0.2 µm filtered solution of 50mM HEPES, pH 7.5, 2mM DTT, 150mM NaCl, 10%glycerol .
    
    Storage
    
    Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
    
    Endotoxin
    
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
    
    More Information
    
    UniProt
    
    P61081
    
    Gene ID
    
    9040
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human NEDD8-Conjugating Enzyme UBC12/UBE2M

Recombinant Human NEDD8-Conjugating Enzyme UBC12/UBE2M

More Information

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