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Overview
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MRPL48 Human Recombinant produced in E. Coli is a single,non-glycosylated polypeptide chain containing 207 amino acids (29-212 a.a) andhaving a molecular mass of 23.1kDa. MRPL48 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Mitochondrial Ribosomal Protein L48, also known as MRPL48, is amammalian mitochondrial ribosomal protein which assists in protein synthesiswithin the mitochondrion. Mitochondrial ribosomes, mitoribosomes, consist of asmall 28S subunit and a large 39S subunit. They include an estimated 75%protein to rRNA composition while comparing to prokaryotic ribosomes, wherethis ratio is reversed. An additional dissimilarity between mammalian mitoribosomes & prokaryoticribosomes is that the latter contain a 5S rRNA. Between different species, theproteins containing the mitoribosome differ very much in sequence, as well as inbiochemical properties from time to time, which prevents easy recognition throughsequence homology. MRPL48 encodes a 39S subunit protein. A pseudogenecorresponding to MRPL48 is found on chromosome 6p.
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Overview