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Recombinant Human Lysosomal Pro-X Carboxypeptidase/PRCP (C-6His)

Recombinant Human Lysosomal Pro-X Carboxypeptidase/PRCP (C-6His)

Catalog Number:
P001411214ABE
Mfr. No.:
Abe32-7767
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      • Overview

        • MW : 54.5kD. Recombinant Human Lysosomal Pro-X Carboxypeptidase is produced by our Mammalian expression system and the target gene encoding Leu22-His496 is expressed with a 6His tag at the C-terminus. Lysosomal Pro-X Carboxypeptidase (PRCP) belongs to the peptidase S28 family. PRCP is detected in many tissues, with highest levels observed in placenta, lung, and liver. It is also present in the heart, brain, pancreas, and kidney. PRCP exists as a homodimer. PRCP cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. PRCP has been shown to be an activator of the cell matrix-associated prekallikrein.

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      • Properties
        • Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Supplied as a 0.2 µm filtered solution of 20mM NaAc-HAc, 150mM NaCl, 10% Glycerol, pH4.5.
          Storage
          Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
          Endotoxin
          Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.

          More Information

          UniProt
          P42785
          Gene ID
          5547

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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