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Overview
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MW : 39.4kD. Recombinant Human IL-18RAcP is produced by our Mammalian expression system and the target gene encoding Phe20-Arg356 is expressed with a 6His tag at the C-terminus. IL-18RAP is a single-pass type I membrane protein and contains two Ig-like C2-type domains and one TIR domain, IL18RAP can be induced by IFN-alpha and IL12 in nature killer cells and T-cells. The coexpression of IL18R1 and IL18RAP is required for the activation of NF-kappa B and JNK in response to IL-18. Defects in IL18RAP are associated with Coeliac disease.
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Overview