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Recombinant human GITR protein with C-terminal human Fc and 6×His tag

Recombinant human GITR protein with C-terminal human Fc and 6×His tag

Catalog Number:
P001417992ABE
Mfr. No.:
Abe32-17018
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      • Overview

        • The protein has a predicted molecular mass of 51-52 kDa after removal of the signal peptide. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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      • Properties
        • Protein Name
          AITR, GITR, TNFRSF18, CD357
          Source
          HEK293 cells
          Type
          Recombinant Proteins
          Purification
          The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
          Formulation
          Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
          Storage
          Store at -80°C for 12 months (Avoid repeated freezing and thawing)

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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