Name: Recombinant human CD33 protein with C-terminal human Fc and 6×His tag
Price: Inquiry

- Overview
  - The protein has a predicted molecular mass of 53.8 kDa after removal of the signal peptide. Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
    
    Please contact us at for specific academic pricing.
- Properties
  - Protein Name
    
    CD33, SIGLEC3, gp67
    
    Source
    
    HEK293 cells
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
    
    Formulation
    
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    
    Storage
    
    Store at -80°C for 12 months (Avoid repeated freezing and thawing)
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Human CD33, hFc-His Tag on SDS-PAGE under reducing condition.

Recombinant human CD33 protein with C-terminal human Fc and 6×His tag

Recombinant human CD33 protein with C-terminal human Fc and 6×His tag

We Also Recommend

msCD40L Recombinant Protein

Recombinant human CD30 Ligand Protein with N-mouse Fc and C-6×His tag

Recombinant human CD70 protein with N-terminal mouse Fc and 6×His tag