Name: Recombinant Human B7 Homolog 6/B7-H6/NCR3LG1(C-6His)
Price: Inquiry

- Overview
  - MW : 27.5kD. Recombinant Human B7 Homolog 6 is produced by our Mammalian expression system and the target gene encoding Asp25-Ser262 is expressed with a 6His tag at the C-terminus. Natural cytotoxicity triggering receptor 3 ligand 1(B7-H6) is a glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H6 consists of a 238 amino acid (aa) extracellular domain (ECD) that contains one Ig-like V domain and one Ig-like C1 domain, a 21 aa transmembrane segment, and a 171 aa cytoplasmic domain that contains one ITIM, one SH2, and one SH3 motif. Both of the Ig-like domains carry N-linked glycosylation. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors.
    
    Please contact us at for specific academic pricing.
- Properties
  - Source
    
    Human cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
    
    Storage
    
    Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.
    
    Endotoxin
    
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
    
    More Information
    
    UniProt
    
    Q68D85
    
    Gene ID
    
    374383
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human B7 Homolog 6/B7-H6/NCR3LG1(C-6His)

Recombinant Human B7 Homolog 6/B7-H6/NCR3LG1(C-6His)

More Information

We Also Recommend

Recombinant Human Macrophage Colony-stimulating Factor 1 Receptor/M-CSF R/CSF1R/CD115(C-Fc)

Recombinant Mouse Interleukin-27/IL-27 (C-6His)

Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 5/CD40(C-6His)