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Overview
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MW : 39.3kD. Recombinant Human Aldo-Keto Reductase 1C4 is produced by our E.coli expression system and the target gene encoding Met1-Tyr323 is expressed with a 6His tag at the N-terminus. Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-a-Androstan-3-a,17- beta-diol (3-a-diol). In addition, AKR1C4 also has some 20-a-Hydroxysteroid Dehydrogenase activity.
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Overview
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